N-type calcium channel

N-type calcium channel Related Products (21):

By Type:	Pan (3) Selective (8)
By Effects:	Inhibitors (9) Agonists (2) Antagonists (8) Activators (2)

Cat. No.	Product Name	Effect	Purity

HY-P0062B

Ziconotide acetate	Antagonist	99.23%
Ziconotide acetate (SNX-111 acetate), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide acetate reduces synaptic transmission, and can be used for chronic pain research.

HY-N0601

Ginsenoside Rf	Inhibitor	99.48%
Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca²⁺ channel.

HY-B0340

Nefiracetam	Activator	99.87%
Nefiracetam is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca²⁺ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research.

HY-12498

GV-58	Agonist	99.22%
GV-58 is a novel N- and P/Q-type calcium (Ca²⁺) channel agonist with EC₅₀s of 7.21 and 8.81 μM, respectively. GV-58 slows the deactivation of channels, resulting in a large increase in presynaptic Ca²⁺ entry during activity. GV-58 can be used in lambert-eaton myasthenic syndrome (LEMS) research.

HY-120751

TROX-1	Inhibitor	99.55%
TROX-1 is a selective, orally active and brain-penetrant N-type calcium channel (Cav2.2) inhibitor with an IC₅₀ value of 0.11 μM. TROX-1 exerts state-dependent and use-dependent inhibition, preferentially targets open/inactivated channels, blocks depolarization-associated calcium influx, and fully blocks calcium influx in rat dorsal root ganglion neurons. TROX-1 reverses inflammatory-induced hyperalgesia, nerve injury-induced allodynia. TROX-1 can be used for the research of pain.

HY-115596

BTT-369	Antagonist
BTT-369 is a Ca_Vα₁·Ca_Vβ₃ protein-protein complex antagonist with a K_i of 2.0 μM. BTT-369 inhibits Ca_V2.2 currents, with an apparent IC₅₀ value of 31 μM. BTT-369 disrupts the interaction between Ca_Vα₁ and Ca_Vβ₃ subunits. BTT-369 reduces the current density of Ca_V2.2, and shifts the voltage dependence of steady-state inactivation and activation of Ca_V2.2 to more positive potentials. BTT-369 alleviates mechanical hyperalgesia in a rat model of tibial nerve injury. BTT-369 can be used for the study of neuropathic pain.

HY-180400

PAM-2	Inhibitor
PAM-2 is a potent, orally active, CNS-penetrant selective α7 nAChR positive allosteric modulator (human α7 nAChR EC₅₀: 39 μM, rat α7 nAChR EC₅₀: 12 μM) with anti-nociceptive and anti-inflammatory activity. PAM-2 exhibits selectivity over α9α10 nAChR (IC₅₀ = 174 μM) and Ca_V2.2 channel (IC₅₀ = 89 μM). PAM-2 decreases Streptozotocin (STZ) (HY-13753)- and Oxaliplatin (HY-17371)-inducned nuroparhic pain in mice by α7 nAChR potentiation. PAM-2 can be used for the research of neuropathic pain.

HY-181612

COX-2/CaV2.2-IN-1	Inhibitor
COX-2/CaV2.2-IN-1 is an orally active and selective dual COX-2/CaV2.2 inhibitor, exhibiting a COX-2 IC₅₀ of 0.26 μM and a CaV2.2 IC₅₀ of 0.29 μM. COX-2/CaV2.2-IN-1 suppresses inflammatory responses and inflammatory mediator (IL-6, TNF-α, NO) production. COX-2/CaV2.2-IN-1 produces pronounced analgesic effects in diverse models of inflammatory, neuropathic, and visceral pain. COX-2/CaV2.2-IN-1 can be used for the research of chronic pain.

HY-14462

NP118809	Inhibitor	98.73%
NP118809 is a potent N-type calcium channel blocker, with an IC₅₀ of 0.11 μM; also less potently inhibits L-type calcium channel with an IC₅₀ of 12.2 μM.

HY-41076

Ca2+ channel agonist 1	Agonist	98.87%
Ca²⁺ channel agonist 1 is an agonist of N-type Ca²⁺ channel and an inhibitor of Cdk2, with EC₅₀s of 14.23 μM and 3.34 μM, respectively, and is used as a potential treatment for motor nerve terminal dysfunction.

HY-132268

Cav 2.2 blocker 2	Inhibitor	98.51%
Cav 2.2 blocker 2 is a Cav2.2 calcium channel blocker extracted from patent WO2017046581A1, compound 1. Cav 2.2 blocker 2 can reverses hyperalgesia associated with an injury or inflammation in conjunction with the opioid.

HY-147638

MONIRO-1	Inhibitor	99.18%
MONIRO-1 is a T-type and N-type calcium channel blocker with IC₅₀ values of 34, 3.3, 1.7 and 7.2 µM against hCa_v2.2, hCa_v3.1, hCa_v3.2 and hCa_v3.3, respectively. MONIRO-1 has low activity against L-type calcium channels. MONIRO-1 can be used for the study of pain and epilepsy.

HY-U00236

PD0176078	Inhibitor	99.80%
PD0176078 is a newly found N-type Calcium channel blocker.

HY-P0062

Ziconotide	Antagonist
Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research.

HY-P0062A

Ziconotide TFA	Antagonist
Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research.

HY-169845

Calcium Channel antagonist 6	Antagonist
Calcium Channel antagonist 6 (Compound 328) is a highly selective antagonist of voltage-gated calcium channel CaV2.2 with an IC₅₀ value of 0.37 μM. Calcium Channel antagonist 6 inhibits of neuron depolarization-induced Ca²⁺ influx. Calcium Channel antagonist 6 is promising for research of neuropathic pain.

HY-147639

Cav 2.2/3.2 blocker 1	Inhibitor
Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker with IC₅₀ values of 78 μM and 80 μM against Ca_v2.2 and Ca_v3.2, respectively. Cav 2.2/3.2 blocker 1 can penetrate the CNS.

HY-131942

sFTX-3.3	Antagonist
sFTX-3.3 is a Ca²⁺ channel antagonist with IC₅₀s of approximately 0.24 mM and 0.70 mM against P-type and N-type channels.

HY-105365

PD 175069	Antagonist
PD 175069 is a potent and selective N-type calcium channel antagonist with an IC₅₀ of 0.32 μM. PD 175069 is efficacious in an audiogenic seizure model using DBA/2 mice. PD 175069 can be used for research on neurological conditions such as neuropathic pain and stroke.

HY-P1078

Huwentoxin XVI	Antagonist
Huwentoxin XVI, an analgesic, is a highly reversible and selective mammalian N-type calcium channel (IC₅₀ of ~60 nM) antagonist from Chinese tarantula Ornithoctonus huwena. Huwentoxin XVI has no effect on voltagegated T-type calcium channels, potassium channels or sodium channels.

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